TLR 3 modulation of hippocampal synaptic activity

9.40 am Motion integration times in sensory cortex are dynamically modified in response to changes in stimulus reliability 10.20 am Mapping molecular diversity of excitatory synapses in the mammalian brain 11.15 am Antidepressant effects on neuronal population dynamics : insights into the role of hippocampus in stress response and adaptive behaviours 11.35 am Preclinical modeling of chronic central neuropathic pain after spinal cord injury: how can we learn from other neuropathic pain models? 1.45 pm Investigating the molecular mechanisms of Anti-NMDA-R encephalitis and its association with ovarian teratomas Dr Sharon King, University of Dundee 2.05 pm A vitamin for all seasons: vitamin A and hypothalamic seasonal control of weight and feeding 2.25 pm Manipulation of activity and cell fate reveal a role for MCH neurons in sleep/wake regulation Dr Tomomi Tsunematsu, Visiting Professor, University of Strathclyde 2.45 pm Distinct contributions of the septal and temporal hippocampus to spatial learning 3.35 pm Active decay of long-term memory:cellular mechanisms & functional contributions of constitutive forgetting Inferring cortical networks underlying human decision making Single-unit animal studies have consistently reported decision-related activity mirroring a process of temporal accumulation of sensory evidence to a fixed internal boundary. To date, our understanding of how response patterns seen in single-unit data manifest themselves at the macroscopic level of brain activity obtained from human neuroimaging data remains limited. Using single-trial analysis of high-density human electroencephalography data, coupled with computational modelling we show that population responses on the scalp reflect the superposition of signals associated with sensory evidence accumulation and other decision-related signals such as choice confidence. Exploiting the trial-to-trial variability in the neural code we decouple these signals and demonstrate that they exert independent leverage on behaviour. Crucially, we also show that decision confidence forms an integral part of the decision process itself rather than reflecting a purely post-decisional signal as suggested by long-standing psychological theories of metacognition. Motion integration times in sensory cortex are dynamically modified in response to change in stimulus reliabitliy. The natural environment presents us with stimuli that have wide range of signal-to-noise ratios. An optimal system would dynamically modulate its responses to reflect this statistical uncertainty. Integrating over long periods when required to smooth out high levels of noise, while responding quickly to changes when the stimulus is highly certain. However, motion perception has been classically modelled as a simple fixed spatio-temporal filter applied in early visual cortex that does not adapt to …